Cyrene’s Synergies with Chrysos Heirs Tier List — HSR 3.7

Ode to Romance → Aglaea

Romance is a one-time cinematic nuke: on use it gives Aglaea “Romantic,” maxes Garmentmaker’s memosprite SPD buff, and on consumption restores 70 Energy, while increasing Aglaea/Garmentmaker DMG by 72% and ignoring 36% of the target’s DEF until she leaves Supreme Stance.

• Use it when you can stall/protect until that single hit lands — pair with shields, taunts, or buffers so Aglaea gets her moment.
• Romance is a match-finisher; the combined ~70 energy refund + 72% DMG boost + 36% DEF ignore makes it a nearly guaranteed way to close out a boss or priority target when properly timed.

Ode to Strife → Mydei

Strife is a clutch, one-use play that removes all Crowd Control on Mydei and then either forces a free Godslayer strike (if Mydei is in Vendetta) with +200% CRIT DMG without consuming Charge, or — if not in Vendetta — advances Mydei’s action by 100%. It’s designed to flip losing turns into finishing turns.

• Use it when you need a guaranteed finisher or to rescue Mydei from CC lockdown — excellent in single-target kill windows or when you must ensure an execute lands.
• Strife is a surgical “oh-crap” button: enormously valuable in clutch situations because it either guarantees a massive crit-laced execution or immediately reorders the turn to regain tempo.

Ode to Life and Death → Castorice

Life and Death expands Castorice’s Newbud overflow to 200% and, when Netherwing is summoned, consumes the overflow to increase the Netherwing DMG multiplier by 0.24% for every 1% overflow consumed; if there are two or fewer enemies, that multiplier gets an additional +0.48% per 1%. This directly converts patient resource stacking into extreme summon damage.

• Use it in boss fights or narrow skirmishes where you can funnel Newbud onto one or two targets — the Ode rewards restraint and precise timing by turning overflow into multiplicative summon power.
• Life and Death is a niche supercharger: when the team is built to hoard Newbud, the summed multipliers become devastating; outside those funneling scenarios it’s far less impactful.

Ode to Sky → Hyacine

Sky grants Hyacine 2 Ode to Sky stacks on use, restores 24 Energy when consumed, and when Hyacine heals while holding a stack it increases Little Ica’s memosprite heal by 72% of that heal value; each Skill/Ultimate consumes one stack. The Ode thus converts energy and stacking into amplified heals.

• Use Sky in long, sustain-heavy fights or teams that rely on HP-scaled shields and repeated heals; it lets Hyacine heal more often and amplify each heal’s impact.
• Sky is a sustain specialist — not flashy, but indispensable when drawn-out durability or repeated HP maintenance is the win condition.

Ode to Reason → Anaxa

Reason refunds 1 Skill Point to allies, lets Anaxa act immediately, adds +3 Skill DMG instances for one turn, and grants “True Knowledge”: +60% ATK to all Erudition allies and +40% Skill DMG until Anaxa’s next turn. It’s a tempo-and-multihit enabler that turns one activation into a multi-skill cascade.

• Use Reason to trigger planned chains — slot it into Erudition teams that scale with skill instances and benefit from synced activations.
• Reason is a high-value, orchestrated play: its combination of SP refund, immediate action, extra instances, and large ATK/Skill-DMG aura makes it ideal for engineered bursts and combo windows where timing and chaining matter.

Ode to Genesis → Trailblazer (Remembrance)

Genesis permanently converts Trailblazer into a crit-leaning carry by boosting ATK by 16% of Cyrene’s Max HP and increasing Trailblazer’s CRIT Rate by 72% of Cyrene’s CRIT Rate, and after Trailblazer uses Enhanced Basic ATK the caster immediately gains 1 extra turn that cannot use an Ultimate. This is a whole-battle reclassification: rather than a one-shot spike, it turns a support window into repeated single-target pressure

• Use it when you plan long boss windows or sustained boss fights where repeated basic-attack pressure pays off — build Cyrene for high HP and high CRIT so those percentage conversions meaningfully inflate Trailblazer’s output.
• Genesis is exceptionally reliable in paced fights because it turns raw defensive or hybrid stats into repeatable damage; slot this Ode when your team’s win condition is steady single-target DPS rather than burst.

Ode to Law → Cerydra

Law is a focused crit tool: it increases CRIT DMG of the character holding “Military Merit” by 30% and—after Coup de Main ends—grants Cerydra 1 Charge, letting her chain follow-ups faster. The Ode temporarily turns a designated crit carry into a harder-hitting, faster actor.

• Use it in tightly orchestrated crit rushes where a “Military Merit” carry is already stacked for crit scaling; pair with crit rate/CRIT DMG supports so the 30% bump lands on already-high crit lines.
• Law is surgical rather than universal — extremely potent in planned crit windows but underwhelming if your squad lacks a dedicated Military Merit crit anchor.

Ode to Trickery → Cipher

Trickery focuses Cipher’s output: it increases Cipher’s DMG by 36%, reduces the Patron target’s DEF by 20%, and reduces non-Patron targets’ DEF by 12%. The result is a persistent, high-pressure funnel that converts spread damage into concentrated execution on a marked target.

• Use it to collapse a priority unit (boss phase, mechanic target) — maintain the Patron mark and coordinate team focus so the DEF shred and 36% damage buff compound.
• Trickery is an excellent execution tool when you can control target priority; it’s less valuable in unfocused or chaotic fights but devastating in planned single-target takedowns.

Ode to Time → Evernight

Time increases Evernight’s memosprite-skill damage by 18% and grants Memoria whenever Evernight uses Skill/Ultimate; additionally the Skill’s CRIT DMG bonus is further increased by 12% of Evernight’s CRIT DMG, so the Ode scales with her own crit investment. It’s designed to make repeat activations snowball.

• Use Time in crit-heavy, repeat-skill loops where Memoria stacks are your engine — it shortens the ramp to critical mass and compounds each activation’s effect.
• Time is one of those “multiplier on repeat” Odes: when Evernight’s build already leans crit and frequent activations, Time turns steady play into exponential returns; otherwise its gains are muted.

Ode to Worldbearing → Phainon

Worldbearing grants 6 Coreflames and Eternal Ignition on transform, and when Coreflame >12 each point beyond grants +12% CRIT DMG (up to +72%); Eternal Ignition also gives +16% CRIT Rate. Extra turns refresh transform windows but each extra turn consumes 15% of current HP, and attacks spawn 5 instances of Additional Fire DMG equal to 10% of ATK. It massively amplifies transform peaks at a steep HP cost.

• Use Worldbearing only in teams that can reliably patch HP with heals, shields, or lifesteal — it’s perfect for transform-centric carries who want extended, explosive windows.
• This Ode is high-risk/high-reward: when sustained, it turns transforms into prolonged damage storms; untreated, the HP drain can undo the advantage.

Ode to Earth → Dan Heng • Permansor

Earth converts shields into offense: it makes the next 3 Souldragon attacks deal Additional DMG equal to 80% of Bondmate’s Shield value, increases Bondmate’s damage by 24%, makes Bondmate shields 150% as strong, and advances Souldragon’s action by 100% while giving the next Souldragon action Dan Heng’s Ultimate enhance. This effectively turns defensive resources into immediate offensive follow-ups.

• Use Earth in shield-centered comps where Bondmate timing and shield scaling are reliable — it’s best when you can schedule a shield then trigger the follow-ups for immediate payoff.
• Earth is a clever utility Ode that converts defensive planning into burst follow-ups; extremely useful in the right shield-synergy roster but niche outside those interactions.

Ode to Passage → Tribbie

Passage makes Tribbie’s multi-hit game more consistent: Tribbie’s damage ignores 12% of enemy DEF and each Follow-up attack triggers one extra instance of Additional DMG (additional damage instances are counted separately from normal attacks). In effect, many small hits stop being weak and become reliable, penetrative pressure.

• Use Passage against tanky or high-DEF enemies where cumulative multi-hit damage outperforms single huge strikes — pair with DoT or multi-hit teammates to amplify the steady bleed of pressure.
• Passage is situational but dependable: it doesn’t create explosive burst, but it converts Tribbie into a predictable damage engine that excels in attrition and prolonged skirmishes.

Ode to Ocean → Hysilens

Ocean is a one-time DoT cash-out: it grants Hysilens “Flowing Warmth,” restores 60 Energy on the first hit, increases Hysilens DMG by 120% for the battle, and causes currently applied DoTs to immediately produce 60%/80% of their original damage on attacks. It converts slow-burning pressure into an instant payout.

• Use Ocean after pre-stacking DoTs in an open where they won’t be prematurely cleared — then detonate to convert accumulated ticks into one massive window.
• Ocean is a planning-oriented game-changer: in planned openings it produces enormous instantaneous numbers; in ad-hoc fights its value falls off if DoTs aren’t already in place.